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GenesNCBI E-utilities (gene)

NCBI Gene

NCBI Gene is the gene database of the National Center for Biotechnology Information, part of the US National Library of Medicine. It gives each gene a stable ID with its official symbol, aliases, map location and a written summary. Through ScholarMuse, an agent calls lookup_gene_protein with a symbol or gene name and gets the matching NCBI Gene record merged with Ensembl and UniProt data.

ScholarMuse tools: lookup_gene_protein. Each successful call uses credits.

Ask your agent

What is the NCBI Gene ID for human BRCA1, and which cytoband is it on?
Give me the NCBI summary and the aliases of mouse Trp53.
Which gene does the name "tumor necrosis factor" refer to in humans, and what is its official symbol?

What your agent gets back

Every record carries id, source, title, url, license, attribution and retrievedAt. The fields below are the data that comes from NCBI Gene.

lookup_gene_protein

The tool returns one merged record. These are the parts filled from NCBI Gene. Field names are paths inside `data`.

ids.ncbiGene
NCBI Gene ID
symbol
Official gene symbol
name
Full gene name
aliases
Other symbols for the gene, up to 12
organism
Scientific name of the organism
summary
NCBI gene summary, cut at 2,000 characters
chromosome
Chromosome the gene is on
cytoband
Map location, for example 17q21.31
location
NCBI coordinates, only when Ensembl has no record
links.ncbiGene
URL of the gene page at NCBI

What it covers

  • Gene records from NCBI Gene: ID, official symbol, full name, aliases, organism, chromosome, map location and summary.
  • Any organism can be requested by NCBI taxon id. Common model organisms (human, mouse, rat, zebrafish, fruit fly, worm, yeast and others) can be requested by name. The default is human.
  • Only current gene records are searched (the query is limited to live records in the chosen organism).

Limits

  • One gene per call. The tool keeps the best match: exact symbol first, then full gene name, then all fields.
  • An organism name outside the built-in list is rejected. Pass its NCBI taxon id instead.
  • No sequences, transcripts, variants or literature links are returned. The summary is cut at 2,000 characters and aliases at 12.
  • A UniProt accession or Ensembl gene id is resolved at those sources first. The NCBI Gene record is then attached only if it can be matched through UniProt's cross-reference or the gene symbol.

How ScholarMuse reaches NCBI Gene

The connector calls NCBI E-utilities directly: esearch on the gene database to find the gene in one organism, then esummary for the record. An NCBI API key is sent when one is configured. Without it the same data comes back, with requests spaced further apart (680 ms instead of 210 ms).

Gene searches are cached for up to 1 day and gene records for up to 7 days, so a recent edit at NCBI can take that long to appear.

API key: the upstream API can be called without one, so you do not add one.

Licence and attribution

Licence: Public domain (NCBI/NLM data usage policies apply)

Gene data from NCBI Gene, National Library of Medicine (ncbi.nlm.nih.gov/gene).

Records that come from NCBI Gene carry this licence and attribution. When you cite the data in a paper, follow NCBI Gene's own citation guidance.

FAQ

ScholarMuse is not an official NCBI Gene product. It is one MCP server for academic data, and its lookup_gene_protein tool queries NCBI Gene. An agent connected to ScholarMuse can use NCBI Gene without a separate server.

No. The NCBI Gene API can be called without a key, and ScholarMuse does not ask you for one. You sign in to ScholarMuse once and your agent calls the tool.

The connector calls NCBI E-utilities directly: esearch on the gene database to find the gene in one organism, then esummary for the record. An NCBI API key is sent when one is configured. Without it the same data comes back, with requests spaced further apart (680 ms instead of 210 ms). Gene searches are cached for up to 1 day and gene records for up to 7 days, so a recent edit at NCBI can take that long to appear.

Public domain (NCBI/NLM data usage policies apply). Attribution: Gene data from NCBI Gene, National Library of Medicine (ncbi.nlm.nih.gov/gene). Records that come from NCBI Gene carry this licence and attribution.

Yes. Each successful call to lookup_gene_protein uses credits, and a call that fails is not charged. Current price: Gene & protein lookup, 1 credit / call.